Search results for "GDNF RET GFRalfa-1 GFRalfa-2 Brain injury In situ hybridization"

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Time-course of GDNF and its receptor expression after brain injury in the rat

2008

Abstract The aim of the present work was to perform, by in situ hybridization, a time-course analysis of the glial cell line-derived neurotrophic factor (GDNF) and its receptor mRNA expression in two models of brain injury in the rat: (a) excitotoxic lesion by ibotenic acid injection in the hippocampal formation; (b) mechanical lesion by needle insertion through the cerebral cortex including the white matter of the corpus callosum. The time-course analysis, ranging from 6 h to 8 days, showed that the GDNF and its receptor (RET, GFRα-1 and GFRα-2) mRNA expressions were differentially up-regulated in both models of lesion. This in vivo regulation of the GDNF and its receptor mRNA expression i…

MalePathologymedicine.medical_specialtyGlial Cell Line-Derived Neurotrophic Factor ReceptorsTime FactorsReceptor expressionCentral nervous systemBiologyHippocampal formationSettore BIO/09 - FisiologiaLesionchemistry.chemical_compoundNeurotrophic factorsGlial cell line-derived neurotrophic factormedicineAnimalsGlial Cell Line-Derived Neurotrophic FactorRNA MessengerRats WistarIbotenic AcidGeneral NeuroscienceGDNF RET GFRalfa-1 GFRalfa-2 Brain injury In situ hybridizationRatsmedicine.anatomical_structureGene Expression Regulationnervous systemchemistryCerebral cortexBrain Injuriesbiology.proteinAutoradiographymedicine.symptomIbotenic acidNeuroscience Letters

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